文章基本信息
- 标题：Evaluation of Hepatoprotective and In-vitro Cytotoxic Activity of Leaves of Premna serratifolia Linn
- 本地全文：下载
- 作者：Rajendran Vadivu ; A. Jerad Suresh ; K Girinath 等
- 期刊名称：Journal of Scientific Research
- 印刷版ISSN：2070-0237
- 电子版ISSN：2070-0245
- 出版年度：2008
- 卷号：1
- 期号：1
- 页码：145-152
- 语种：English
- 出版社：Rajshahi University
- 摘要：Premna serratifolia is used by the traditional practitioners as cardiotonic, antibiotic, anti-coagulant, stomachic, carminative, hepatoprotective, antitumor etc. The present study aims in the evaluation of hepatoprotective and in-vitro cytotoxic activity of alcoholic extract of leaves of Premna serratifolia Linn. Hepatoprotective activity is studied by carbon tetrachloride induced hepato-toxicity in rats and the in-vitro cytotoxic activity is carried out by tryphane blue exclusion method using EAC cell lines. The degree of protection in hepatoprotective activity has been measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin and total protein. The results suggest that the alcoholic extract at the dose level of 250mg/kg has produced significant  ( p The alcoholic extract also does exhibit the IC 50 value of 75µg/ml which indicates the significant in-vitro cytotoxic activity of the extract . It is concluded that alcoholic extract of leaves of Premna serratifolia Linn is not only an effective hepatoprotective agent, but also possesses significant antitumor activity.  Keywords: Premna serratifolia Linn; Alcoholic extract hepatoprotective; In-vitro cytotoxic activity.  © 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.  DOI: 10.3329/jsr.v1i1.1046 Â
- 关键词：Premna serratifolia Linn;Alcoholic extract hepatoprotective;In-vitro cytotoxic activity.
