Hemifacial microsomia--a case report.
Hren, Natasa Ihan ; Drstvensek, Igor
1. INTRODUCTION
The human face holds many functions (eating, speaking, nonverbal
communication etc) which combined with its appearance define and affect
human psychosocial activities. Severe facial deformities, either
congenital, traumatic or consequences of tumour removal are treated by
reconstructive surgery procedures. The bone defects in maxillofacial
region can be replaced by patients' own bone by different surgical
principles as bone grafts or by engineering bone by distraction
osteogenesis (Bell, 1992). These different autogenous bone grafts are
"golden standard" for reconstruction procedures because they
provide osteogenic cells, but they are of limited quantity and connected
with risk of complications on donor site (Ellis III, 2003). The
allogenic grafts or homografts are taken from another individual of the
same species and need a lot of preparations before being used not to
induce immunologic response; similar is with bone from unhuman species.
So the need for bone substitutes--xenogenic grafts was the generator of
great progress in developing inorganic bone substitutes, as
biotechnology of bone cells cultivating. All these materials have
advantages and disadvantages, but there is no ideal material yet. A good
synthetic material needs to have following properties: biocompatibility,
inertness, bone-similar weight or even lighter, capability to generate
no artefacts on CT and MRI scans, ease of manufacturing, enough strength
to resist functional stress, not being expensive and low or no thermal
conductivity.
2. OBJECTIVES
The article presents the treatment of a severe facial deformity,
where surgical procedures with autogenous bone graft, distraction
osteogenesis, prefabricated and custom made xenogenic bone grafts were
performed. Twenty four year old mentally healthy man was born with
hemifacial microsomia. This is a severe asymmetry of facial bone and
soft tissues in vertical, sagital and transverse plane combined with
hearing impairment on the affected side (Proffit, 2003). He wasn't
treated before his adulthood; all surgical procedures were done in
Clinical department of maxillofacial and oral surgery, University
clinical centre Ljubljana. He was treated by classical ortognathic
surgical procedures (Le Fort I osteotomy and autogenous bone grafting)
and by a modern surgical technology as distraction osteogenesis of
mandible. After these bone surgical procedures the remaining defect of
bone and soft tissues was partially compensated with on-lay xenogenic
graft, later replaced with custom made titanium angular implant. His
images before and after surgical procedures are presented on fig.1.
[FIGURE 1 OMITTED]
3. METHOD
The treatment of an adult patient with hemifacial microsomia has
the goal to achieve bone symmetry as good as possible, more difficult is
to compensate the soft tissue deficiency. In presented patient the first
surgery procedure was producing vertical part of his left lower jaw by
distraction osteogenesis (fig.2).
Than his upper jaw was elongated and rotated by LeFort I osteotomy
and his autogenous bone grafting (fig. 3). Because of the transverse
discrepancy the on-lay xenogenic graft (Medpore mandible on-lay graft)
was performed, but it was removed after more than one year because of
the inflammation. Than we decided for custom made titanium angular
implant (fig. 4), which was prepared on the basis of computer tomography
(CT) scans, Computer Aided Design (CAD) and Rapid Manufacturing
technologies (Laboratory for Intelligent Manufacturing Systems, of the
University of Maribor, Faculty of Mechanical Engineering).
[FIGURE 2 OMITTED]
4. IMPLANT PRODUCTION
The production of bone implants starts by capturing a
three-dimensional data set of the problematic area (scull, face,
mandibular area ...). Usual and the most common way is transformation of
sets of CT or MRI two-dimensional pictures into a three-dimensional,
digital model. The model is then used as a base on which the modeling of
defective--missing area takes place. If the defect is positioned in an
area that has its "mirror image" on another side of the body
than the form of the implant can relatively easily be produced by means
of Boolean operators. In a case of "mirror less" features some
more sophisticated methods and dedicated software have to be used to
finish the implant. Presented case study deals with mirroring and some
special finishing methods performed by dedicated animation software.
Mirrored model of the jaw was used as a reference for modeling of the
implant using standard CAD approaches. In a case of a jaw and other
bones with attached muscle tissues simple Boolean subtraction can not be
used to model a final shape of the implant. Positions of muscle
attachments need to be taken in consideration, therefore the mirrored
model is only used as guidance for shaping cross section polylines. The
polylines are later used to guide a modeling of implant surfaces that
shape the final form of the implant.
[FIGURE 3 OMITTED]
Finished digital model is then manufactured by one of the Rapid
Manufacturing (RM) technologies. RM products are usually made of
titanium or cobalt--chrome alloys since these are at the moment the only
biocompatible materials available for RM technologies that can be
directly used as implants. Research is going on in the field of so
called Bio-plotters that are able to manufacture parts from
bio-compatible and even biodegradable materials but there has not been a
commercial brake-through yet what makes these technologies useless for
surgical praxis.
[FIGURE 4 OMITTED]
5. DISSCUSION
The presented case report is an example of different surgical
procedures used to correct a facial deformity with different surgical
procedures. With standard orthognatic procedures (osteotomies of the
bone, their correction in the position and volume) we can achieve better
facial function and harmony, but not perfect (Cheng, 1998). The
distraction osteogenesis is very innovative approach for forming
patient's own bone (Samchucov, 2000) but at least in one dimension
the quantity is not ideal (Bell & Guerrero, 2007). So there is still
the need for xenografts as bone substitutes--in the majority of the
facial deformity cases for esthetic correction of bone or soft tissue
defects.
6. CONCLUSIONS
The medical needs and contemporary technological development are
the fields that will be in close relation in the future in many fields
of the medicine. For facial deformities, in spite of different surgical
approaches, there is still a need for development of materials for
xenogenic bone grafts and the technologic facilities can nowadays
prepare custom made bone implants to achieve better esthetical results.
7. REFERENCES
8.
Bell, WH. (1992). Modern practice in orthognatic and reconstructive
surgery. W. B. Saunders company, Philadelphia.
Bell, WH. & Guerrero, CA. (2007). Distraction osteogenesis of
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Cheng, LHH.; Roles, D. & Telfer, MR. (1998). Orthognatic
surgery: the patients' perspective. Brit J Oral Maxillofac Surg
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Ellis III, E. (2003). Surgical reconstruction of defects of the
jaw. In: Peterson,; Ellis,; Hupp, & Tucker. Maxillofacial surgery,
4rd edition. Mosby, New York, 646-659,
Proffit, WR. & Turvey, TA. Dentofacial asymetry. In: Proffit,
WR.; White, RP. & Sarver, DM. (2003). Contemporary Treatment of
Dentofacial Deformity. Mosby, St. Louis, 574-621,
Samchucov, ML.; Cope, JB. & Cherkashin, AM. (2000).
Craniofacial distraction osteogenesis. Mosby, St Louis.