Evaluation of the biological activity of Balanites aegyptiaca (L.) Del Saponin in the control of type 11 diabetes mellitus on rats and the growth of Escherichia coli.

George, Dina Hilal William ; Ali, Hana Kamal Mohammed ; Abbas, Omer Abbas Elamin 等

The research was conducted to highlighted, fix the attention on and evaluate the effect of different pure saponin extract concentrations from Balanites aegyptiaca fruit in the control of type 11 Diabetes mellitus and in the inhibition of Escherichia coli growth. The Balanites aegyptiaca is known to be widely used in this field in the Sudan.

The study was carried out with pure saponin, which was previously extracted from the balamites fruit mesocarp, and the water extract of saponin was used as an oral hypoglycemic agent. The saponin extract was orally given to albino rats in different concentrations dose: (1) 10 mg/kg, dose (2) 20mg/kg and dose (3) 40 mg/kg respectively.

The rats were divided into five groups; three of them were given the three doses. The fourth and the fifth were given Daonil (as a standard medication) and water. The saponin extract effect in lowering the blood glucose levels was compared to that of standard drug which was Daonil. The groups were compared in terms of two variables that is dose and time.

Pure saponin was dissolved in distilled water to yield different saponin concentrations.

This results confirmed the objectives of the research in that Balanites aegyptiaca pure saponin had a significant impact on the control of type II Diabetes mellitus compared with Daonil and on the inhibition of Escherichia coli growth in rats.

Dina Hilal William George, Hana Kamal Mohammed All and Omer Abbas Elamin Abbas (School of Health Sciences, Ahfad University for Women)