摘要:Major Depressive Disorder (MDD) prevalence is above 10% and it is one of the main causes for suicide in recent times. Moreover, it is a common medical condition that can present itself in a chronic and recurrent form, triggering biopsychosocial disabilities. In this light, effective and lasting interventions for this disorder are needed. Cognitive-Behavioral Therapy intends to propose interventions with structured techniques, and its effectiveness is demonstrated in some studies. This article aims to discuss a case study of a 31-year old patient with MDD. She was treated in a school clinic with a Cognitive Behavioral referential. After 20 sessions, positive results were obtained with easing of core beliefs and increasing repertoire of strategies to solve problems. With the decrease of symptoms the patient had significant changes in her relationships. Key words: Major Depressive Disorder, Cognitive Behavioral Therapy, Case Study.