期刊名称：Revista Internacional de Contaminación Ambiental
印刷版ISSN：0188-4999
出版年度：2010
卷号：5
期号：1
页码：49-58
出版社：Centro de Ciencias de la Atmósfera
摘要：Cytogenetic effects of the diazinon were analyzed in bone marrow cells of mice injected intraperitoneally (i.p.). Five different endpoints were examined: sister chromatid exchanges (SCE's), chromosomal aberrations (CA), mitotic index (MI), cell cycle kinetics, and average generation time (AGT). Results show a significative increased in both, SCE's and CA. Diazinon at 43 and 54 mg/Kg produce a significative reduction in MI, a increase in first-cycle metaphase and decrease in second-and third cycle metaphases, while the AGT were significantly increased. For the analysis of teratogenic effects, diazinon was administered i.p. to pregnant rats. Data shows no effects in the total number of implants at two dose levels tested, however a dose-related increase of resorptions, and significant fetal body weight depression was observed in al1 doses. Examination of the fetuses revcaled significant incidcnces of some gross and skeletal altcrations. These results indicates that diazinon may be considerated as potentially mutagenic, embryotoxic, and teratogenic in vivo.
