This paper develops theoretical standpoints to investigate and analyse university inventors and patenting activities. Although the studies on academic entrepreneurship and university patenting have substantially increased, first there have not been enough studies on individual inventors and second the current theoretical studies are not eclectic enough to capture the different factors that may explain university inventors patenting activities. The framework described here addresses this need. To accomplish this we inductively derive several factors from a substantial number of studies on university patenting and entrepreneurship, and develop these factors into a tentative framework. It is our hope that this framework is useful in future empirical research on university patenting and provides a point of departure for scientists.