This study identified knowledge and concerns about avian influenza among secondary school students in Taif, Saudi Arabia. A stratified random sample of 514 students from 6 secondary schools was given a self-administered multiple-choice questionnaire. Knowledge scores were significantly related to socioeconomic indicators. Approximately 70% of the participants reported that media (TV and/or radio) was the source of their information. Overall, 65.4% of the participants said they expected there to be cases of avian influenza in Saudi Arabia this year. Females were more concerned than males (70.9% versus 58.9%). Effective school health education programmes should be implemented in order to prepare the community to deal with this important threat.