This study described the characteristics of mental health research from the Islamic Republic of Iran published from 1973–2002. Research articles in psychiatry, psychology and neuroscience published in local or international journals were drawn from IranPsych, a national database of research in mental health and related disciplines. Of 3113 articles, 21.8% appeared in international journals, but there was international collaboration among the authors in only 2.3%. There was a marked increase in the number of publications over time, especially in the last 5 years. Analysis of research areas showed a proportionate rise in neuroscience research and a decline in mental health service research. Our study provides an empirical basis for policy-making and strategy planning in the nation’s mental health research.