The recent focus in asthma management is rendering children a better quality of life (QOL). Validity and reliability of an adapted Arabic translation of the Paediatric Asthma Quality of Life Questionnaire (PAQLQ-A) among Egyptians was assessed in a cohort of 103 asthmatic children aged 8–16 years. Discriminative validity of mean scores was significantly higher among mild asthmatics than those with moderate/severe asthma. Construct validity of domains was significantly negatively correlated with clinical severity score. Reliability and internal consistency were assessed using Cronbach alpha coefficient (α = 0.84). Reproducibility and responsiveness were high among both stable and unstable asthma patients. PAQLQ-A is valid and reliable for assessing QOL among Egyptian asthmatic children.