Early experience of abuse may be viewed as a risk factor for mental disorders in women later in life. This case–control study in Isfahan screened 709 women aged 20–45 years using the Beck Depression Inventory and structured clinical interviews for Diagnostic Statistical Manual–IV criteria. Lifetime history of abuse was determined using a standard questionnaire. Among the women 35.1% had experienced fear of or actual abuse (physical, sexual or both) in childhood or adolescence. The risk of having major depression in adult life was significantly higher in women who experienced abuse in childhood and adolescence (OR 4.3), severe degrees of abuse (OR 3.9) or multiple forms of abuse (OR 3.8).