标题：Within-microenvironment exposure to particulate matter and health effects in children with asthma: a pilot study utilizing real-time personal monitoring with GPS interface
期刊名称：Environmental Health - a Global Access Science Source
印刷版ISSN：1476-069X
电子版ISSN：1476-069X
出版年度：2016
卷号：15
期号：1
页码：96
DOI：10.1186/s12940-016-0181-5
语种：English
出版社：BioMed Central
摘要：Most particulate matter (PM) and health studies in children with asthma use exposures averaged over the course of a day and do not take into account spatial/temporal variability that presumably occurs as children move from home, into transit and then school microenvironments. The objectives of this work were to identify increases in morning PM exposure occurring within home, transit and school microenvironments and determine their associations with asthma-related inflammation and rescue medication use. In 2007–2008, thirty Denver-area schoolchildren with asthma performed personal PM exposure monitoring using a real-time sensor integrated with a geographic information system (GIS) to apportion exposures to home, transit and school microenvironments. Concurrently, daily monitoring of the airway inflammatory biomarker urinary leukotriene E4 (uLTE4) and albuterol usage was performed. Mean PM exposures each morning were relatively well correlated between microenvironments for subject samples (0.3 < r < 0.8), thus limiting use of this exposure metric to attribute health effects to PM exposure in specific microenvironments. Within-microenvironment increases in exposure, such as would be characterized by one or a series of transient spikes or a sustained increase in concentration (exposure event), however, were not strongly correlated between microenvironments (|r| < 0.25). On days when children were exposed to a ≥ 5μg/m3 exposure event during transit, they demonstrated a 24.0 % increase in uLTE4 (95 % CI: 1.5 %, 51.5 %) and a 9.7 % (−5.9 %, 27.9 %) increase in albuterol usage compared to days without transit exposure events. Associations between exposure events and health outcomes in home and school microenvironments tended to be positive as well, but weaker than for transit. School children with asthma moving across morning microenvironments experience spatially heterogeneous PM exposures with potentially varying health effects.
关键词：Spatio-temporal ; Aerosol ; Air pollution ; Inflammation ; Epidemiology
