期刊名称：SORT-Statistics and Operations Research Transactions
印刷版ISSN：2013-8830
出版年度：2016
卷号：1
期号：1
页码：31-54
语种：English
出版社：SORT- Statistics and Operations Research Transactions
摘要：In this paper two alternative estimation procedures based on the EM algorithm are proposed forthe flexible negative binomial cure rate model with a latent activation scheme. The Weibull modelas well as the log-normal and gamma distributions are also considered for the time-to-event datafor the non-destroyed cells. Simulation studies show the satisfactory performance of the proposedmethodology. The impact of misspecifying the survival function on both components of the model(cured and susceptible) is also evaluated. The use of the new methodology is illustrated with areal data set related to a clinical trial on Phase III cutaneous melanoma patients.
关键词：Competing risks, EM algorithm, latent activation scheme
