期刊名称：Walailak Journal of Science and Technology (WJST)
印刷版ISSN：2228-835X
出版年度：2015
卷号：13
期号：10
页码：789-802
语种：English
出版社：Institute of Research and Development, Walailak University.
摘要：A series of compound 6-bromo-3-(6-substitutedphenyl)-2-(morpholinomethylamino) pyrimidin-4-yl)-2H-chromen-2-one ( BT 1 M-T 10 M ), 3(2-((piperidin-1-yl) methylamino)-6- (2-substitutedphenyl) pyrimidin-4-yl)-6-bromo-2 H -chromen-2-one ( BT 1 P-BT 10 P ) has been synthesized from 3-(2-amino-6 -pyrimidin- 4-yl)-6- bromo- 2H-chromen-2-one ( T 1 -T 10 ). The structures of the synthesized compounds were elucidated by I.R., 1 HNMR, elemental analysis and mass spectroscopic techniques. The synthesized compounds were screened for in-vivo anti-inflammatory activity at a dose of 50 mg/kg body weight by a carrageenan-induced rat paw edema method. Among them, compounds BT 8 M , BT 4 P , BT 5 P , and BT 7 P exhibited significant anti-inflammatory activity. Compounds BT 3 M , BT 9 M , BT 10 M , BT 9 P , and BT 10 P showed highly significant anti-inflammatory activity. The remaining compounds showed less anti-inflammatory activity, comparable to that of standard drug diclofenac sodium.
关键词：Pyrimidine, anti-inflammatory activity, rat paw edema
