期刊名称：Walailak Journal of Science and Technology (WJST)
印刷版ISSN：2228-835X
出版年度：2011
卷号：5
期号：1
页码：47-56
语种：English
出版社：Institute of Research and Development, Walailak University.
摘要：We isolated strain SA14 that produced an antibacterial agent against Staphylococcus aureus and clinical isolates of methicillin-resistant S. aureus from air samples and identified it to be Brevibacillus laterosporus using API 50 CHB strips. It showed a broad range of antibacterial activity against bacteria in contaminated drinking water such as Escherichia coli and Pseudomonas and even the opportunistic microorganism Candida albicans , when investigated by the cross streak method. It excreted antimicrobial peptides into culture broth on the first day of cultivation. The peptide molecular weight determined by SDS-PAGE was 116 kDa. Characteristic measurements indicate that the peptides had a relatively gram-positive bacteria inhibitory spectrum, especially, S. aureus and MRSA, when investigated by agar well diffusion. The anti-MRSA activity was not affected by a wide pH, chemical compounds and temperature range.
