期刊名称：Proceedings of the Canadian Engineering Education Association
出版年度：2011
语种：English
出版社：The Canadian Engineering Education Association (CEEA)
摘要：A novel approach was taken in the fourth year design course for Chemical Engineers. A complex pharmaceutical process for the manufacturing of Clopidogrel Bisulfate (CPG), an anti-platelet drug, was successfully designed and simulated using AspenBatch™ and SuperPro Designer (SPD) software packages. Two models were applied in the design of the crystallizer and dryer, which provided the optimal cooling rate for crystallization and the surface area of the dryer. The solubility of CPG in acetone was determined experimentally by Attenuated Total Reflectance Fourier Spectroscopy (ATR-FTIR) instrument. Multifunctional equipment were designed to reduce the production and maintenance costs.
