文章基本信息

标题：Nilotinib therapy after resistance and intolerance to imatinib in CML patient with trisomy of the chromosome 8
作者：Antonella Russo Rossi
期刊名称：Clinical Management Issues
印刷版ISSN：2283-3137
出版年度：2015
卷号：4
期号：5S
页码：23-27
语种：Italian
出版社：SEEd
摘要：In this article is presented the case of a 30-year-old woman with chronic myeloid leukaemia (CML) treated with imatinib for 15 months, and then with nilotinib as second-line therapy. Two episodes of grade 3 neutropenia, the detection of the trisomy of chromosome 8 and the failed achievement of a major molecular response (MMolR) in 15 months led to the switch to nilotinib. With nilotinib the patient obtained the lack of the genetic anomaly in 3 months and a complete molecular response (CMolR) in 6 months, all confirmed at 9 months. No haematologic or extra-haematologic adverse events were detected with this second-line agent.
关键词：Chronic myeloid leukemia;Nilotinib;Intolerance to imatinib;Neutropenia imatinib-related