The purposes of this study were to (1) study and develop the measurement of 5 minds for 21st century, (2)develop the 5 components of minds, (3) develop the 5 minds development program, (4) compare the scoringsfrom the measurement of 5 minds for 21st century before and after participating in intervention, and (5) study theeffectiveness of the mind developed program. Participants were 333 nurse students; of those, 32 students wereincluded in the experiment group. Simple random sampling was used to assign students into two groups.Instruments were the 5 minds for 21st century scale, and psychological group training the 5 minds for 21stcentury program. Data was analyzed by using Confirmatory Factor Analysis, Wilcoxon Match Pair SignedRanks Test, and Mann Whitney U Test, respectively. The measurement of 5 minds for 21st century included 70items with the Likert scale ratings, and the Cronbach’s Alpha was .935. The confirmatory factor analysis showedstatistic significant difference in five components of minds, and these were integrated in to 12 activities ofpsychological group training-5 minds for 21st century program. The researcher found that psychological grouptraining could be used to develop 5 minds because this program showed the effectiveness at an adequate level.Study showed statistically significant differences in the mean scores of minds in the experimental group betweenbefore and after participating in the program, except the Respectful mind component.