Non-pharmacological approaches such as the cognitive-behavioral strategies and pathological information do not treat the underlying pain and do not change pain perception but somehow reduce the emotional responses to the pain. In this regard, the study has examined the effect of consulting to reduce the anger based on acceptance and commitment between children and adolescents with cancer. This study is a semi-experimental and research project, pre-test and post-test with control and follow-up period. The study sample was included all 242 children with cancer admitted in Seydoshohada Hospital of Isfahan province in 2014. The number of 30 subjects is selected among the population including 15 experimental and 15 control groups. To collect information a demographic questionnaire is used and the Nilsson anger questionnaire (2000) is used to analyze the data by the SPSS Software. The results show that the effect of counseling on anger component changes in children with cancer is statistically significant. This means that the consulting in the form of acceptance and commitment leads to reduce the signs of anger in children with cancer (0.01> P). For this reason and given the results of the study the hypothesis was proved.