This study aimed to investigate the effect of Pilates on resiliency and psych-asthenia of the housewives in Tehran. The most common problems of the housewives included decreased resilience and uniform life that led to increased psych-asthenia. Using the knowledge of Contrology, measuring the effect of Pilates on resiliency and psych-asthenia of the housewives was considered. Quasi-experimental research design included the control groups (pre-test, post-test). The statistical population consisted of 40 housewives (20 in Pilates group and 20 in control group) that were selected using the available sampling by referring to a sports club in District 2, Tehran. Data were analyzed using analysis of variance and multivariate analysis of covariance, and the adjusted comparison was conducted at the significance level of 5%.The results showed that the adjusted mean of the scores of resiliency and psych-asthenia for the intervention group are significantly different (p>5.0) and there is a significant difference between the mean scores of resiliency and psych-asthenia of the treatment and control groups. Pilates exercises increase resiliency and decrease psych-asthenia of the housewives. Thus, it is recommended that psychologists and psychiatrists consider Pilates as a supplementary treatment in their prescriptions.