The study examined prediction of teenager depression based on social skill, peer attachment, parental attachment and self-esteem. The type of this study is descriptive-corolation. Data from survey of 382 high school daughter students in basis of morgan sampling table were used. At this study we used Multistage Cluster Method for sampeling. Information of this study collecting by Kutcher Adolescent Depression Scale (2002), Social Skills Inventory and Foster teen Ayndrbytzn TISS (1992), Test Adolescent Attachment to Parent and Peer (IPPA-R) (1978) and Ruchester Self-Esteem Scale (1998). The Statistical method used for data analysis in the study is Multivariable regression and Pearson correlation. The results indicated that there was reversed significant relation between teenager Depression and Social Skills. There was also reverse significant realation between Depression, Peer and Parent Attachment and Self-Esteem. Furthermore it revealed that between mother attachment and father attachment, mother attachment had more share on prediction of adolescence depression. Among three variables of social skills, parental attachment, peer attachment and self-esteem the social skill had the least effect on prediction of adolescent depression but others had a significant effect.