The mediostructure, that is the system of cross-referencing, is a lexicographic device that can be used to establish relations among different components of a dictionary. This paper focuses on different mediostructural strategies and their practical application in general synchronic dictionaries. The structure of dictionaries is discussed from a metalexicographic perspective in order to explain the system of cross-referencing. It is shown how textual cohesion, achieved by the interaction of the various structural components, is promoted by the use of a system of cross-referencing and improved by an innovative approach towards a mediostructure-orientated lexicography.