期刊名称：REBAC - Revista Brasileira de Análise do Comportamento
出版年度：2016
卷号：10
期号：2
语种：Portuguese
出版社：REBAC - Revista Brasileira de Análise do Comportamento
摘要：In order to investigate whether early malnutrition causes lasting changes in the reactivity to anxiolytic drugs, rat dams lactation (21 days) and pops after weaning until the 49 th day of life were fed on 8% casein diet (M rats), while their well-nourished controls received 25% casein (W rats), from day 50 on all animals ate the same balanced diet. Experiments started on the 91 st day. Rats deprived for 22 hours drank water containing either 1.8% or 2.7% sodium chloride for 30 min in a test chamber, total intake being measured. Dose-effect curves for diazepam (0.5-5.0 mg/kg, IP), as well as for the monbenzodiazepine anxiolytics ipsapirone (0.5-5.0 mg/kg), ritanserin (0.05-1.0 mg/kg) and isamoltane (2.5-20.0 mg/kg) were determined in M as well as in W rats. Diazepam and ipsapirone dose-dependently released drinking suppressed by either salt concentration in W rats, but caused little or no effect in M rats. Ritanserin and isamoltane were ineffective in both groups. These and previously reported results show that early protein malnutrition markedly reduces anticonflict effect of anxiolytics, indicating long-lasting impairment of neuronal systems underlying emotional behavior. Keywords : early protein malnutrition, hypertonic saline intake, diazepam, ipsapirone.
