The aim of this study is to determine the relationship between social desirability, self-efficacy, and responsibility and communication skills of high school students in Ahvaz city. The sample of this study has been consisted of 360 participants that have been selected by cluster sampling method. This research is a descriptive and correlational study. The tools that have been used in this research are: Social Desirability questionnaire of Crowne and Marlowe (1960), the responsibility questionnaire of Harrison (1999), general self-efficacy questionnaire of Scherer et al. (1982) and communication skills questionnaire of Harjy and Marshall (1986). The data has been analyzed by using the statistical methods of Pearson correlation and multiple regressions. The results have shown that there is a positive relationship between social desirability, self-efficacy, responsibility and communication skills of students. The results of multiple regression analysis have shown that social desirability and responsibility and self-efficacy are respectively the best predictors of communication skills.