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  • 标题:Building and Documenting Workflows with Python-Based Snakemake
  • 作者:Johannes K{\"o}ster ; Sven Rahmann
  • 期刊名称:OASIcs : OpenAccess Series in Informatics
  • 电子版ISSN:2190-6807
  • 出版年度:2012
  • 卷号:26
  • 页码:49-56
  • DOI:10.4230/OASIcs.GCB.2012.49
  • 出版社:Schloss Dagstuhl -- Leibniz-Zentrum fuer Informatik
  • 摘要:Snakemake is a novel workflow engine with a simple Python-derived workflow definition language and an optimizing execution environment. It is the first system that supports multiple named wildcards (or variables) in input and output filenames of each rule definition. It also allows to write human-readable workflows that document themselves. We have found Snakemake especially useful for building high-throughput sequencing data analysis pipelines and present examples from this area. Snakemake exemplifies a generic way to implement a domain specific language in python, without writing a full parser or introducing syntactical overhead by overloading language features.
  • 关键词:workflow engine; dependency graph; knapsack problem; Python; high-throughput sequencing; next-generation sequencing
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