Water pollution through wastewater is a serious problem in Mexico. For this reason, the possibility of contamination of aquifers is latent. In the literature there are reports that some aquifers are contaminated, on the other hand the country has been divided into aquifers 653 101 are overexploited, they provide 58% of groundwater intended for all uses. Consequently it is important study the aquifers to meet its water quality and take action to prevent contamination and to not put at risk the health of users. The aim of this study is to determine the bacteriological and physicochemical quality of the groundwater in Morelos state which, for administrative purposes, is divided into four aquifers Cuernavaca, Zacatepec, Cuautla-Yautepec and Tepalcingo-Axochiapan. From 2005 to 2010, bi-monthly samples were drawn from each aquifer for one year to find out if there are contaminated areas to take action. Principal use of water in this state is urban and agricultural. In total, thirty-seven wells were sampled. Aquifer Tepalcingo-Axochiapan showed marked difference in the dissolved solids respect to the other aquifers. The average physicochemical parameters were below the levels permitted by the NOM-127-SSA1-1994, on water for human consumption. Bacteriologically, all the wells showed contamination in at least one sample. Nevertheless, although the dilution capacity of the aquifer has so far prevented the water quality from deteriorating, there are already areas where anthropic contamination is evident.