This study is a survey of the application of scientific methods to research among librarians in South East Nigeria. It examines the purpose for the application of scientific methods to research, as well as the obstacles that librarians in South east Nigeria face in their bid to apply scientific methods to research. Survey method was adopted for the study, while a structured questionnaire was used as instrument for data collection. 120 questionnaires were distributed to librarians; 88 representing 73.3% were filled and returned. Result of the study shows that librarians use scientific methods in carrying out research. It also shows that librarians applied scientific methods to research for the main purpose of analyzing data and testing hypothesis. The study further revealed that application of scientific methods to research in librarianship helps the profession to be more scientific in outlook and also helps in collation and analyzes of data to solve professional problems. Lastly, It identified lack of funds as a major obstacle to the application of scientific methods to research among librarians in South east Nigeria. The study recommended the need for government at both National and State levels to provide funds for scientific research in librarianship, considering the benefits of such researches to library and national development. There is also need for the Nigeria Library Association to organize awareness programmes to enlighten librarians on the need to apply scientific methods in their research investigations.