The aim of this study is to identify prevalence of drug use and to examine undergraduate students’ perceived risks of substance use in Timis County area. This study is part of a type A grant financed by the National University Research Council. We conducted a cross sectional study using a multistage stratified cluster sample design to produce a representative sample of undergraduate students for Timis County, Romania. A 126-item questionnaire was developed to investigate health-risk behaviours of young adults. Eighteen items regarding illicit drug use suggesting different intensity of use were listed. The response categories were “no risk”, “slight risk”, “moderate risk”, “great risk” and “don’t know”.