To compare the accuracy and clinical usefulness of different devices by measuring anterior chamber depth (ACD) with three devices and central corneal thickness (CCT) with four devices.

In 180 eyes of 90 healthy subjects, ACD was measured using A-scan, Lenstar LS900®, Pentacam®, and CCT was measured using ultrasound pachymetry (USP), Lenstar LS900®, Pentacam®, and anterior segment optical coherence tomography (OCT).

The average ACT measurements using Lenstar LS900®, A-scan, and Pentacam® were 3.27 ± 0.35 mm, 3.26 ± 0.36 mm, and 3.25 ± 0.36 mm, respectively. The measurements were significantly correlated ( p < 0.001) but without statistically significant difference ( p = 0.017). The Bland-Altman plots showed a low degree of agreement. The average CCT measurements using Pentacam®, USP, Lenstar LS900®, and OCT were 553.31 ± 25.23 µm, 547.26 ± 23.83 µm, 541.38 ± 24.49 µm, and 531.40 ± 22.33 µm, respectively. The measurements were significantly correlated ( p < 0.001) and statistically significantly different ( p < 0.05). The Bland-Altman plots showed a low degree of agreement.

ACD and CCT measured using different devices were highly correlated, but the ACD measurements were not statistically different; however, the CCT measurements were statistically different, and agreement was low between both measurements.