This report is 5 anesthetic experiences of renal transplantation performed from October 1972 to May 1973 at Central Operating Theater, Seoul National University Hospital. The major considerations about renal transplantation are the states of anemia, uremia, acidosis, electrlytes imbalance with hyperpatassemia, hypertension and immunological problems. In anesthetic management, the following must be considered: 1) Operative method. 1. Concomitant transplantation with nephrectomy 2. Transplantation followed by nephrectomy 2) Duration of operation 3) Degree of hypertension 4) Degree of anemia 5) Degree of pulmonary function 6) Intraoperative arterial blood analysis.