The authors have experienced two cases of general anesthesia for operation of congenital tracheo-esophageal fistula and the results were obtained as follows. 1. The anesthetic agent should be selected as considering of lesser irritating to respiratory system and smaller amount of tracheobronchial secretion. 2. The infant circle absorber system has been preferred to the Ayres T-piece apparatus, because maintaining normal body temperature and removal of carbon dioxide easily. 3. Removal of secretion from trreheobronchial tree, intermittent positive pressure breathing, maintaining normal body temperature and humidity were thought to be necessary for the prevention and treatment of postogerative pneumonia or atelectasis.