We have introduced a method of intermittent injections of thalamonal and concomitant use of small doses of pentothal for rapid and smooth loss of consciousness and induction of anesthesia, and maintaining anesthesia with intermittent injections of thalamonal and pancuronium bromide as well as N₂O inhalation. From 20 geriatric patients, the following results were obtained. 1) Average dose of thalamonal during induction of anesthesia was 0.75±0.28ml/10kg and that of pentothal was l. 77±0. 44 ml/kg. The maintenance of anesthesia was achieved by the intermittent injection of thalamonal; the average dose was 0.118±. 0.08 ml/10 kg/30 min. 2) During induction, the average decrease of systolic blood pressure was 22. 5 mmHg (P<0. 05) and the pulse rate increased in 1.9/min (P>0. 1). 3) During induction, 3 cases among 20 showed moderate chest rigidity and 4 cases showed hypotension. The hypotension may be due to the additive effect of pentothal and droperidol. 4) At the end of operation, after the administration of 510 mg nalorphine, the respiratory rate increased from 13. 8/min to 19. 3/min (P <0. 01). 5) 18 cases among 20 recovered promptly after discontinuation of N₂O inhalation with delay in 2 cases. Postoperatively one person complained of nausea and a small dose of narcotic pain control was needed in 3 persons.