The purpose of this systematic review was to ascertain the current state of science regarding the use of turmeric and its pigment curcumin in individuals with Alzheimer’s Disease (AD). A summary of qualitative and quantitative evidence specific to the effect of curcumin on AD is presented in this article. The purpose of the review was to evaluate and summarize findings related to this body of research. Findings indicated a positive correlation between administration of turmeric and improvement AD symptoms; however, long-term benefits need to be researched. Also, experimental research with older adults with mild, moderate, and severe AD should be conducted to determine whether or not turmeric and curcumin improve cognition, depression, and agitation. Specific methodological issues that need to be considered are the dosage and purity of turmeric and curcumin, administration frequency, determination of a suitable placebo, and duration of testing.