文章基本信息
- 标题：Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment
- 本地全文：下载
- 作者：Moon K. Song ; David S. Bischoff ; Albert M. Song 等
- 期刊名称：BBA Clinical
- 印刷版ISSN：2214-6474
- 出版年度：2017
- 卷号：7
- 页码：41-54
- DOI：10.1016/j.bbacli.2016.09.003
- 出版社：Elsevier B.V.
- 摘要：Highlights
•
Alzheimer's Disease is called Type 3 Diabetes as associated with Type 2 Diabetes.
•Insulin degrading enzyme treats both Alzheimer's Disease and Type 2 Diabetes.
•Cyclo(His-Pro) plus zinc treats both Alzheimer's Disease and Type 2 Diabetes.
Background
Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D) has been well established. Cyclo(His-Pro) plus zinc (Cyclo-Z) treatment ameliorated diabetes in rats and similar improvements have been seen in human patients. Treatment of amyloid precursor protein (APP) transgenic mice with Cyclo-Z exhibited memory improvements and significantly reduced Aβ-40 and Aβ-42 protein levels in the brain tissues of the mice.
Scope of review
Metabolic relationship between AD and T2D will be described with particular attention to insulin sensitivity and Aβ degradation in brain and plasma tissues. Mechanistic effect of insulin degrading enzyme (IDE) in decreasing blood glucose and brain Aβ levels will be elucidated. Cyclo-Z effects on these biochemical parameters will be discussed.
Major conclusion
Stimulation of IDE synthesis is effective for the clinical treatment of metabolic diseases including AD and T2D.
General significance
Cyclo-Z might be the effective treatment of AD and T2D by stimulating IDE synthesis.
- 关键词：Diabetes; Alzheimer's Disease; Metabolic disease; Cyclo(His-Pro); Zinc; Insulin degrading enzyme
