文章基本信息

标题：Antidepressant-Like Effect of 1α-Hydroxyvitamin D3 on Mice in the Forced Swimming Test
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作者：Akihiko KAWAURA ; Yoshihisa KITAMURA ; Noritoshi TANIDA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2017
卷号：63
期号：1
页码：81-84
DOI：10.3177/jnsv.63.81
出版社：Center for Academic Publications Japan
摘要：We examined the effect of 1α-hydroxyvitamin D₃ [1α(OH)D₃] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D₃ reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D₃ had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D₃ may have antidepressant-like activity.
关键词：1α-hydroxyvitamin D3;forced swimming test;glial cell line-derived neurotrophic factor;brain-derived neurotrophic factor