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  • 标题:Designing allostery-inspired response in mechanical networks
  • 本地全文:下载
  • 作者:Jason W. Rocks ; Nidhi Pashine ; Irmgard Bischofberger
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2017
  • 卷号:114
  • 期号:10
  • 页码:2520-2525
  • DOI:10.1073/pnas.1612139114
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of networks. With nearly complete success, we are able to produce a strain between any two target nodes in a network in response to an applied source strain on any other pair of nodes by removing only ∼1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic 2D and 3D systems that exhibit these responses. This work is inspired by the long-range coupled conformational changes that constitute allosteric function in proteins. The fact that allostery is a common means for regulation in biological molecules suggests that it is a relatively easy property to develop through evolution. In analogy, our results show that long-range coupled mechanical responses are similarly easy to achieve in disordered networks.
  • 关键词:mechanical metamaterials ; allostery ; tunable response ; proteins ; disordered networks
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