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  • 标题:Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes
  • 本地全文:下载
  • 作者:Vicente Andreu-Fernández ; Mónica Sancho ; Ainhoa Genovés
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2017
  • 卷号:114
  • 期号:2
  • 页码:310-315
  • DOI:10.1073/pnas.1612322114
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The Bcl-2 (B-cell lymphoma 2) protein Bax (Bcl-2 associated X, apoptosis regulator) can commit cells to apoptosis via outer mitochondrial membrane permeabilization. Bax activity is controlled in healthy cells by prosurvival Bcl-2 proteins. C-terminal Bax transmembrane domain interactions were implicated recently in Bax pore formation. Here, we show that the isolated transmembrane domains of Bax, Bcl-xL (B-cell lymphoma-extra large), and Bcl-2 can mediate interactions between Bax and prosurvival proteins inside the membrane in the absence of apoptotic stimuli. Bcl-2 protein transmembrane domains specifically homooligomerize and heterooligomerize in bacterial and mitochondrial membranes. Their interactions participate in the regulation of Bcl-2 proteins, thus modulating apoptotic activity. Our results suggest that interactions between the transmembrane domains of Bax and antiapoptotic Bcl-2 proteins represent a previously unappreciated level of apoptosis regulation.
  • 关键词:apoptosis ; Bcl-2 ; mitochondria ; oligomerization ; transmembrane
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