摘要：Polymorphisms of HLA-A, and -B antigens were investigated in the Kyrgyz population living in the northeastern part of Central Asia. Serological typing for HLA-A and -B loci was performed in 157 healthy unrelated blood donors. The frequent HLA-A antigens were A2 (29.2%), A24 (20.6%), and A1 (10.4%). For HLA-B loci, B51 (10.6%), B17 (9.1%), B13 (8.7%), and B35 (8.5%) were predominant. Multidimensional scaling and phylogenetic analysis were performed based on the gene frequencies of HLA-A and -B. In the multidimensional scaling for 24 worldwide populations, Kyrgyz situated itself close to other Central Asian populations. In the phylogenetic tree, Kyrgyz were included in the cluster of Central Asian, while they located close to the European cluster. Four HLA-A-B haplotypes, A2-B blank (5.7%), A2-B13 (4.7%), A24-B51 (3.9%), and A2-B17 (3.7%) were observed at frequencies of more than 3%. These haplotypes, except for A2-B blank have been observed in European and/or Asian populations. The present results well agree with the hypothesis, which has been proposed in morphological studies, that Kyrgyz have been derived from not only Mongoloid but also Caucasoid ancestors.
