期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1986
卷号：1
期号：1
页码：31-37
DOI：10.3164/jcbn.1.31
出版社：The Society for Free Radical Research Japan
摘要：The effects of prostaglandin (PG)I2 and (E)-3-[4-(1-imidazol-methyl)phenyl]-2-propenoic acid hydrochloride monohydrate (OKY-046), a thromboxane A2 synthetase inhibitor, on endotoxin-induced experimental disseminated intravascular coagulation (DIC) were studied in rats. Experimental DIC was induced by a 4h sustained infusion of endotoxin at a dose of 100mg/kg of body weight. Rats were infused continuously with PGI2 at 2.4×10-7-1.2×10-4g/kg or with OKY-046 at 2.4×10-8-2.4×10-4g/kg into a femoral vein for 4h. Simultaneously with the agent infusion, endotoxin (100mg/kg/4h) was administered into the contralateral femoral vein. A protective effect against DIC was noted in the rats treated with 2.4×10-5 or 1.2×10-4g/kg of PGI2, or with 2.4×10-8-2.4×10-4g/kg of OKY-046 with respect to the following parameters: fibrinogen and fibrin degradation products, fibrinogen level, prothrombin time, partial thromboplastin time, platelet count, and the number of renal glomeruli with fibrin thrombi. These results demonstrated that PGI2 or OKY-046 reduces the extent of changes of the coagulation parameters caused by DIC.
