期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1986
卷号：1
期号：2
页码：143-149
DOI：10.3164/jcbn.1.143
出版社：The Society for Free Radical Research Japan
摘要：The mechanism of triglyceride (TG) deposition in adipose tissue in man still remains to be elucidated. In order to analyze interrelationships among insulin secretion, circulating triglyceride, and obesity, 22 juveniles with dynamic obesity (increasing obesity), 21 juveniles with static obesity (stationary obesity) and 16 non-obese control juveniles were examined for pancreatic B-cell function together with several plasma parameters. Hyperinsulinism was found both in dynamic and static obese groups when judged from 24-h urinary excretion rates of insulin and C-peptide. Interestingly, only the dynamic obesity group showed mild, but significant, elevations of plasma TG and total cholesterol; whereas both obesity groups revealed similar increases in plasma TG-carrier apolipoprotein B levels associated with hyperinsulinism. HDL-cholesterol and carrier apolipoprotein A-I levels were decreased in both obesity groups. The results suggest that the elevations of insulin and apolipoprotein B levels are common conditions of obesity and the degree of obesity seems to increase via hyperphagia and subsequent increase in the transport of TG-rich lipoproteins from the liver to adipose tissue.
关键词：dynamic obesity;static obesity;hyperinsulinism;triglyceride;apolipoprotein B
