期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1991
卷号：10
期号：2
页码：113-118
DOI：10.3164/jcbn.10.113
出版社：The Society for Free Radical Research Japan
摘要：Dietary deprivation of fat in male Swiss mice for 6 weeks resulted in a decrease in cytochrome c -reductase (Cyt. c -red.) activity without alteration of the activities of arylhydrocarbon hydroxylase (AHH), aminopyrene demethylase (APD), and cytochrome P-450 (Cyt. P-450) in the liver, whereas levels of glutathione-S-transferase (GST) and reduced glutathione (GSH) were significantly increased by fat-free diet feeding. Following N-nitrosodiethylamine (NDEA) administration, AHH, APD, and Cyt. P-450 significantly declined, whereas GST and GSH were stimulated in the liver of control as well as fat-deficient mice. NDEA treatment decreased the activities of AHH and APD, and increased the GST activity in the lungs of fat-deficient mice only. The higher levels of GST and/or GSH in fat deficiency may have a protective role in chemical carcinogenesis.
