期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1992
卷号：13
期号：1
页码：13-22
DOI：10.3164/jcbn.13.13
出版社：The Society for Free Radical Research Japan
摘要：The present study was conducted to investigate the effect of specific fatty acid esters on lipid metabolism of rats fed diets containing highly purified fatty acid ethyl esters of palmitate, stearate, palmitoleate, oleate, linoleate, and alpha linolenate. The hypocholesterolemic and hypotriglyceridemic activity of palmitoleate was comparable with that of linoleate and alpha linolenate and was significantly greater than that of palmitate, stearate, and oleate. Plasma cholesterol and LDL-cholesterol were significantly higher in rats fed the palmitate diet than those fed the stearate one. Lecithin-cholesterol acyltransferase (LCAT) activity was higher in rats fed the palmitoleate, linoleate, and alpha linolenate than in rats fed the palmitate, stearate, and oleate. There was a highly negative correlation between LCAT activity and plasma cholesterol and free cholesterol levels. These results demonstrate that palmitoleate appears to be as effective as linoleate in lowering plasma cholesterol and triglyceride levels. The stearate does not strongly increase plasma cholesterol levels as much as palmitate.
