期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1992
卷号：13
期号：1
页码：45-51
DOI：10.3164/jcbn.13.45
出版社：The Society for Free Radical Research Japan
摘要：Glucose intolerance and impaired insulin secretion in vitamin D deficiency, and altered vitamin D metabolism in streptozotocin- or alloxan-induced diabetes, are well established in experimental animals. No such data are available in humans. The present study was conducted on a group of uncontrolled diabetic patients: those with non-insulin-dependent diabetes mellitus (NIDDM: 42) and those with insulin-dependent diabetes mellitus (IDDM: 6). After an initial oral glucose tolerance test, each subject was given one intramuscular injection of vitamin D (vitamin D3: 300, 000IU), and the oral glucose tolerance test was then repeated after 4 weeks. Administration of vitamin D resulted in a significant improvement in the oral glucose tolerance, serum calcium, and also glucose-stimulated increase in serum insulin levels. Possible mechanism(s) of this beneficial effect of vitamin D on human diabetes is discussed.
