期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1992
卷号：13
期号：3
页码：161-167
DOI：10.3164/jcbn.13.161
出版社：The Society for Free Radical Research Japan
摘要：The effect of dietary oleic acid on lipid metabolism was investigated in SD rats. Different types of oleic acid (ethyl oleate, triolein, olive oil, and high-oleic sunflower oil) were compared with ethyl linoleate and fat-free diets for their efficacy in lowering the plasma cholesterol concentration. Plasma cholesterol concentrations were significantly higher in rats fed ethyl oleate and olive oil than in those fed triolein, high-oleic sunflower oil, ethyl linoleate, or the fat-free diet. The lowest plasma cholesterol concentration was observed in rats fed ethyl linoleate. Chylomicron plus VLDL and LDL-cholesterol concentrations were more markedly increased in rats fed the oleic acid-rich diets, especially ethyl oleate and olive oil, than in those fed the ethyl linoleate diet. HDL-cholesterol concentrations were not different among the experimental groups. LCAT activity in rats fed the ethyl linoleate was twice as high as that in any other group. These data suggest that oleic acid-rich oil does not induce a hypocholesterolemic response in rats fed hypercholesterolemic diets.
