期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1993
卷号：14
期号：2
页码：113-119
DOI：10.3164/jcbn.14.113
出版社：The Society for Free Radical Research Japan
摘要：Change in serum lipid peroxide level was examined in rats undergoing acute or chronic rejection of heart transplants, in order to clarify the role of lipid peroxides in the development of graft coronary disease. In the rat heart transplantation model under acute rejection conditions, the serum lipid peroxide level of the recipients did not change. While, in the chronic rejection model the level of the recipients significantly increased on the 15th day after the transplantation as compared with that of sham-operated control rats. Light microscopic observations of an allograft on the 15th day after the operation revealed the presence of inflammatory lesions involving infiltration of lymphocytes into the myocardium, edema, and necrosis. On the 22nd day after the operation, intimal thickening in the coronary artery was observed, and it became more remarkable on the 50th day. These results suggest that the increase in serum lipid peroxide level could be one of the signs of graft coronary disease.
