期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1993
卷号：15
期号：3
页码：195-202
DOI：10.3164/jcbn.15.195
出版社：The Society for Free Radical Research Japan
摘要：The protective effect of two types of vitamin E (α-tocopherol and γ-tocotrienol) in rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were studied by determination of plasma alkaline phosphatase (ALP), plasma and liver microsomal γ-glutamyl transpeptidase (GGT) activities, and blood glutathione (GSH). Rats treated with DEN/AAF had significantly elevated plasma and microsomal GGT, plasma ALP activities, and blood GSH levels compared with the normal controls ( p <0.05). Supplementation with vitamin E of normal controls did not affect the enzyme activities or blood GSH. In rats treated with DEN/AAF, vitamin E supplementation attenuated GGT and ALP activities and blood GSH levels. The optimum dose required for highest attenuation of the tumor marker enzyme activities was 34mg/kg diet for α-tocopherol and 30mg/kg diet for γ-tocotrienol. Higher doses of the vitamin did not show further attenuation in the level of the tumor marker enzyme activities.
