期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1994
卷号：17
期号：1
页码：47-54
DOI：10.3164/jcbn.17.47
出版社：The Society for Free Radical Research Japan
摘要：The effect of chronic ethanol administration on intestinal uptake of D-glucose, L-glycine, and L-leucine was studied in rats maintained on rat pellet (RP) or semisynthetic diets rich in either saturated (coconut oil; CCO) or unsaturated (n-6, corn oil; CO or n-3, fish oil; FO) triacylglycerols. The fish oil diet enhanced sodium-coupled uptake of glucose and glycine as compared with the diets containing RP, CCO, or CO. The rate of Na+-dependent leucine uptake was in the order of RP=CO+-dependent glucose and glycine uptake. The CCO diet abolished the ethanol-induced decrease in glucose and glycine uptake. Leucine uptake was decreased in ethanoltreated CCO or FO groups only. Sodium independent uptake of the solutes remained unaltered upon ethanol ingestion. Kinetic studies revealed differences in the values of maximum velocity and affinity constants. These observations suggest that the type of dietary lipids has an important bearing on the absorptive properties of rat small intestine in response to ethanol.
