期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1995
卷号：18
期号：1
页码：49-54
DOI：10.3164/jcbn.18.49
出版社：The Society for Free Radical Research Japan
摘要：When 10-week-old male BALB/c mice received whole-body irradiation with a sublethal 4-Gy single dose of 60Co γ-ray, the occurrence of leucopenia caused by the irradiation was lessened to some extent by subcutaneous injection of 2-hydroxyestradiol (2-OHE2), one of catecholestrogens, given 3h before and 3h after the irradiation. Upon irradiation, the weight of the thymus was reduced, but the recovery of organ weight was markedly accelerated by subcutaneous injection of 2-OHE2. Light microscopic observation revealed that 2-OHE2 prevents the reduction by γ-ray irradiation of cortical and medullary volumes of the thymus. These results indicate that 2-OHE2 is a potent radioprotector.
关键词：catecholestrogen;60Co γ-ray;anemia;leukopenia;atrophy of thymus
