期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1995
卷号：18
期号：2
页码：65-71
DOI：10.3164/jcbn.18.65
出版社：The Society for Free Radical Research Japan
摘要：Echitamine chloride was tested for its anti-cancer effect on fibrosarcoma cells and far toxicity toward vero cells, a representative “normal” cell. In vitro incubation of these cells with different concentrations of echitamine chloride demonstrated the non-toxic nature of this drug on vero cells and its anti-cancer effect on sarcoma cells. The latter included reductions in cell viability, glutathione content, and [3H]-thymidine incorporation and increased lipid peroxidation. Interestingly, echitamine chloride caused 55% cell death at a concentration of 200μM in the case of sarcoma cells whereas vero cells were not affected even at the maximum concentration tested, i.e., 200μM.
