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  • 标题:In Vitro Evaluation of the Anti-Cancer Effects of Echitamine Chloride on Fibrosarcoma Cells
  • 本地全文:下载
  • 作者:Pachiyappan KAMARAJAN ; Nalini RAMAMURTHY ; Saminathan GOVINDASAMY
  • 期刊名称:Journal of Clinical Biochemistry and Nutrition
  • 印刷版ISSN:0912-0009
  • 电子版ISSN:1880-5086
  • 出版年度:1995
  • 卷号:18
  • 期号:2
  • 页码:65-71
  • DOI:10.3164/jcbn.18.65
  • 出版社:The Society for Free Radical Research Japan
  • 摘要:Echitamine chloride was tested for its anti-cancer effect on fibrosarcoma cells and far toxicity toward vero cells, a representative “normal” cell. In vitro incubation of these cells with different concentrations of echitamine chloride demonstrated the non-toxic nature of this drug on vero cells and its anti-cancer effect on sarcoma cells. The latter included reductions in cell viability, glutathione content, and [3H]-thymidine incorporation and increased lipid peroxidation. Interestingly, echitamine chloride caused 55% cell death at a concentration of 200μM in the case of sarcoma cells whereas vero cells were not affected even at the maximum concentration tested, i.e., 200μM.
  • 关键词:vero cells;fibrosarcoma;glutathione;lipid peroxidation;[3H]thymidine incorporation
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