期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1995
卷号：19
期号：2
页码：79-87
DOI：10.3164/jcbn.19.79
出版社：The Society for Free Radical Research Japan
摘要：The effect of pretreatment with Ocimum sanctum , an herbal drug, on HCl-ethanol-induced gastric lesions in rats was investigated with respect to acid/pepsin, lipid peroxidation, antioxidant status, and glycoproteins in the gastric mucosa. The increase in volume and acidity of the gastric juice and the decrease in peptic activity in HCl-ethanol-exposed mucosa were maintained at near normalcy in O. sanctum -pretreated mucosa. The increase in lipid peroxidation, decrease in activity of antioxidants in the ulcerated rats were maintained at normalcy in the pretreated rats. Decrease in protein and glycoprotein of the ulcerated mucosa were found to be maintained to near normal in O. sanctum -treated mucosa. These results suggest that by virtue of its ability to decrease acidity and increase the mucosal defense, the use of O. sanctum as an antiulcerogenic agent is justified.
