期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1995
卷号：19
期号：2
页码：97-105
DOI：10.3164/jcbn.19.97
出版社：The Society for Free Radical Research Japan
摘要：In different stages of carcinoma of the uterine cervix, the activities of serum 5′-nucleotidase, lactate dehydrogenase (LDH), phosphohexose isomerase (PHI), γ-glutamyl transpeptidase (GGT), transaminases, and phosphatases were studied before and after radiation treatment. Glycolytic enzymes (LDH, PHI) were found to be increased from stage I onwards, whereas GGT, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and acid and alkaline phosphatases increased only in the advanced stages (stages III, IV), when compared with normal values. 5′-Nucleotidase was found to be increased significantly from stage II onwards when compared with the normal. The increased levels of these enzymes were reversed to near normal levels after radiotherapy. The increased levels of serum transaminases, phosphatases, and GGT in the advanced stages of carcinoma of uterine cervix may be explained on the basis of liver involvement and bone metastasis. The degree of increase in the activities of PHI and LDH may reflect the status of the cancer. The activity of 5′-nucleotidase in serum may be used as an additional marker to assess the status of carcinoma of uterine cervix under circumstances when other markers fail to provide clear indications.
